PDF全文下载：2017030018
陈传秀，金青*， 谭然然
(青岛科技大学 化工学院，山东 青岛266042)
摘要：制备不同的葡萄糖酸锌外用制剂，采用Franz扩散池和离体小鼠皮进行体外透皮吸收实验，测其10 h的单位面积累积透过量，研究不同基质及不同透皮促进剂作用下葡萄糖酸锌的透皮吸收性能。结果表明：葡萄糖酸锌在不同基质中的透皮吸收速率从大到小为卡波姆凝胶＞CMC-Na水凝胶＞W/O乳膏＞凡士林油膏，且体外释放动力学均符合Higuchi方程。在卡波姆凝胶剂中，对葡萄糖酸锌促渗作用最好的为2%（质量分数）谷氨酸钠;W/O乳膏剂中，3%（质量分数）二甲亚砜对葡萄糖酸锌的促渗作用最好。葡萄糖酸锌在以2%（质量分数）谷氨酸钠为促渗剂，卡波姆940凝胶为基质时具有较好的透皮吸收。
关键词： 葡萄糖酸锌；透皮吸收；透皮吸收促进剂
中图分类号： R 944.9文献标志码：A
引用格式：陈传秀，金青，谭然然.葡萄糖酸锌透皮吸收性能的研究\[J\].青岛科技大学学报（自然科学版），2017，38（3）：18-21.
CHEN Chuanxiu, JIN Qing, TAN Ranran.Study on percutaneous absorption of zinc gluconate\[J\].Journal of Qingdao University of Science and Technology（Natural Science Edition),2017,38(3)：18-21.
Study on Percutaneous Absorption of Zinc Gluconate
CHEN Chuanxiu, JIN Qing, TAN Ranran
(College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao 266042, China)
Abstract: To study effects of matrixes and penetration enhancers on the zinc gluconate in vitro, different zinc gluconate penetration dosage forms was prepared by type of penetration enhancers. Using Franz diffusion cell and excised male mice skin as model, accumulative permeation quantity were fitted. The results indicated that the order of percutaneous amount of zinc gluconate was Carbomer gel ＞CMC-Na＞W/O cream ＞Vaseline ointment during 12 h.The concentration of sodium glutamate at 2% had maximum enhancing effect for zinc gluconate in Carbomer gel and the concentration of dimethyl sulfoxide at 3% had maximum enhancing effect for zinc gluconate in W/O cream, and zinc gluconate release process belong to Higuchi equation. We can concluded that zinc gluconate with Carbomer gel as matrix and 2% sodium glutamate as permeability enhancer shows nice drug transdermal delivery effects.
Key words: zinc gluconate; percutaneous absorption; penetration enhancer
收稿日期：2015-10-20
作者简介：陈传秀(1990—)，女，硕士研究生.*通信联系人.
文章编号：16726987（2017）03001804； DOI： 10.16351/j.1672-6987.2017.03.003
