2-苄基-6-对甲苯磺酰基-2，6-二氮杂螺［3,3］庚烷的合成

PDF全文下载：2017010019

李秀芬，黄龙江，滕大为*

(青岛科技大学 化工学院，山东 青岛266042)

摘要：以三溴新戊醇为原料，经与对甲苯磺酰胺环合、环醚开环、羟基活化、环合等4步反应以58%的收率合成了目标产物，相比已有合成方法，该合成路线以甲磺酰基（-OMs）离去基替代溴原子，提高了收率、简化了反应的操作和后处理，适合工业化生产。

关键词：三溴新戊醇；2，6-二氮杂螺［3,3］庚烷； 合成

中图分类号：O 062文献标志码：A

引用格式：李秀芬，黄龙江，滕大为.2-苄基-6-对甲苯磺酰基-2，6-二氮杂螺［3,3］庚烷的合成［J］.青岛科技大学学报(自然科学版), 2017, 38(1): 1923.

LI Xiufen, HUANG Longjiang, TENG Dawei.Synthesis of 2benzyl6tosyl2,6diazaspiro［3,3］heptane［J］.Journal of Qingdao University of Science and Technology（Natural Science Edition), 2017, 38(1): 1923.

 Synthesis of 2-Benzyl-6-tosyl-2,6-diazaspiro［3,3］heptane

LI Xiufen, HUANG Longjiang, TENG Dawei

(College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao 266042, China)

Abstract: The 2-benzyl-6-tosyl-2,6-diazaspiro［3,3］heptane was synthesized by the reaction of cyzlization with p-toluenesulfonamide, ring opening of ether, activation of hydroxyl group and cycalization from pentaerythritol tribromide as raw material with 58% total yield. By using the methylsulfonyl group (-OMs) instead of Br, the mod-ified synthetic route is privileged with higher yield, more simple operation and especially suitable for industrial production.

 Key words: pentaerythritol tribromide; 2,6-diazaspiro［3,3］heptanes; synthesis

 收稿日期：20150828

基金项目：山东省自然科学基金项目（ZR2014BL028）.

作者简介：李秀芬（1976—），女，讲师.*通信联系人.

文章编号：16726987（2017）01001905；DOI：10.16351/j.16726987.2017.01.003