脯氨酸类催化剂催化2庚基环戊酮的BaeyerVilliger氧化反应

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文章编号： 16726987（2021）01001406； DOI： 10.16351/j.16726987.2021.01.002

陈蕊蕊a， 于凤丽b， 于世涛a*(青岛科技大学 a.化工学院；b.化学与分子工程学院，山东 青岛 266042）

摘要： 以L脯氨酸和不同Brnsted酸为原料，通过一步法合成出一系列脯氨酸类催化剂，用于催化2庚基环戊酮的BaeyerVilliger氧化反应。筛选出具有适宜酸度和氧化性的［ProH］H2PW12O40表现出最佳的催化活性。优化出［ProH］H2PW12O40催化的最佳反应条件：n(2庚基环戊酮)=01 mmol，n(［ProH］H2PW12O40)=0004 mmol，n(30%H2O2)=035 mmol，T=50 ℃，t=6 h。在最佳条件下，2庚基环戊酮的转化率为9722％，δ十二内酯的选择性是8233％。反应结束后，用水萃取催化剂并除水干燥，便可实现重复利用。经过4次循环后，其催化活性没有明显下降。［ProH］H2PW12O40可用于催化多种环酮的BaeyerVilliger氧化，结果表明［ProH］H2PW12O40具有良好的底物普适性。

关键词： 脯氨酸； BaeyerVilliger氧化； 2庚基环戊酮； δ十二内酯

中图分类号： O 624.4文献标志码： A

引用格式： 陈蕊蕊， 于凤丽， 于世涛. 脯氨酸类催化剂催化2庚基环戊酮的BaeyerVilliger氧化反应\[J\]. 青岛科技大学学报（自然科学版）， 2021, 42(1): 1419.

CHEN Ruirui, YU Fengli，YU Shitao. BaeyerVilliger oxidation of 2heptylcyclopentanone catalyzed by prolinebased catalysts\[J\]. Journal of Qingdao University of Science and Technology（Natural Science Edition), 2021, 42(1): 1419.

BaeyerVilliger Oxidation of 2Heptylcyclopentanone

Catalyzed by Prolinebased Catalysts

CHEN Ruiruia, YU Fenglib， YU Shitaoa

(a.College of Chemical Engineering；b. College of Chemistry and Molecular Engineering,

Qingdao University of Science and Technology, Qingdao 266042, China)

Abstract: By using Lproline and different Brnsted acids as raw materials, a series of prolinebased catalysts are synthesized by onestep synthesis, and used for catalyzing BaeyerVilliger oxidation of 2heptylcyclopentanone. The catalyst of ［ProH］H2PW12O40 owing to its suitable acidity and oxidizability exhibits the best catalytic activity. The optimization is carried out to obtain the optimum reaction conditions: n(2heptylcyclopentanone)=01 mmol，n(［ProH］H2PW12O40)=0004 mmol，n(30%H2O2)=035 mmol，T=50 ℃, t=6 h. Under the optimal conditions, the conversion of 2heptylcyclopentanone is 9722%, and the selectivity of δdodecarolactone is up to 8233%. After the reaction, the catalyst ［ProH］H2PW12O40can be extracted by water, dried, and reused. After four cycles, there is no significant decrease in catalytic activity. ［ProH］H2PW12O40 is also used to catalyze the BaeyerVilliger oxidation of various cyclic ketones, and the results show that ［ProH］H2PW12O40 has a general applicability for substrates.

Key words: proline; BaeyerVilliger oxidation; 2heptylcyclopentanone; δdodecarolactone

收稿日期： 20191225

基金项目： 国家自然科学基金项目（21878166）;山东省重点研发计划项目(2017GGX70102).

作者简介： 陈蕊蕊（1995—）,女，硕士研究生.*通信联系人.