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文章编号： 16726987（2018）06003506； DOI： 10.16351/j.16726987.2018.06.005
崔晓军， 宋小雨， 玄光善*
(青岛科技大学 化工学院，山东 青岛 266042）
摘要： 制备了褐藻多糖硫酸酯（FPS）的缓释片，并对其释放特性进行考察。以羟丙基甲基纤维素（HPMC）、羧甲基纤维素钠（CMCNa）和十八醇为骨架材料，采用湿法制粒制备FPS缓释片，并用响应面法优化其处方，通过测定SO2-4的含量来评价FPS缓释片的体外释放度。响应面优化结合实际，FPS缓释片的最优处方为FPS占片重的41%，HPMCK4M、CMCNa、十八醇、乳糖、硬脂酸镁分别占片重的20%、20%、13%、5%和1%；此处方下制备的缓释片2，6，12 h可分别释放药物32%、64%和92%，体外药物释放行为符合一级模型，并以Fick扩散和骨架溶蚀2种机制协同作用释放药物。通过响应面优化得到了最优处方，最优处方下制备的FPS缓释片体外缓释效果良好。
关键词： FPS； 缓释片； 响应面； 释放度
中图分类号： R 944.4文献标志码： A
引用格式： 崔晓军， 宋小雨， 玄光善. 褐藻多糖硫酸酯缓释片的制备及体外释放特性\[J\]. 青岛科技大学学报（自然科学版）， 2018， 39（6）： 3540.
CUI Xiaojun， SONG Xiaoyu， XUAN Guangshan. Preparation and in vitro release of fucoidan sustainedrelease tables\[J\]. Journal of Qingdao University of Science and Technology（Natural Science Edition), 2018, 39(6)： 3540.
Preparation and in Vitro Release of Fucoidan SustainedRelease TablesCUI Xiaojun， SONG Xiaoyu， XUAN Guangshan
(College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao 266042, China) Abstract: To prepare FPS sustainedrelease tables and evaluate its release characteristics in vitro. FPS sustainedrelease tables were prepared by wet granulation,using HPMC,CMCNa and octadecanol as matrix materials and prescription was optimized by the response surface design;the release of FPS sustainedrelease tables was determined by determining the amount of SO2-4.Under the response surface optimization combined with practice,the optimum prescription was determined as follows: The weight percents of FPS,HPMC,CMCNa,octadecanol, lactose and magnesium stearate were 41%,20%, 20%,13%,5% and 1% respectively.The cumulative release value of the active drug was 32%, 64% and 92% respectively in the 2, 6 and 12 h. Our data illustrated that the drug release behavior of the tablets is line with the firstorder release pattern and the drug is released driven by a combination of Fick diffusion and skeletal dissolution effects.Under the best prescription,the release characteristics of FPS in vitro are satisfactory.
Key words: FPS； sustnedrelease tablets； response surface design； release rate
收稿日期： 20170905
基金项目： 国家自然科学基金项目（31760521）.
作者简介： 崔晓军（1991—），女，硕士研究生.*通信联系人.
