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吕志果，李星星，郭振美
(青岛科技大学 化工学院，山东 青岛266042）
摘要:手性与生命现象休戚相关,通过手性催化剂进行不对称催化合成反应是获得手性化合物最有效的方法。铑与膦配体形成的络合物催化烯烃的不对称氢甲酰化反应合成光学活性醛具有反应活性高、选择性好等优点，在药物、农药、香料和天然产物合成方面具有重要作用。本研究介绍了不对称氢甲酰化反应的可能反应机理，重点介绍了几类代表性的手性膦配体在此类反应中的应用，各种手性膦配体的研究进展以及手性合成中所面临的问题，并对手性离子液体催化剂的工业应用前景进行了展望。
关键词:手性配体;不对称氢甲酰化（AHF）;铑金属;烯烃
中图分类号：TQ 073文献标志码：A
引用格式：吕志果，李星星，郭振美.P-Rh不对称氢甲酰化手性催化体系研究新进展\[J\].青岛科技大学学报（自然科学版），2017，38（2）：18-26.
LYU Zhiguo, LI Xingxing, GUO Zhenmei.New progress of P-Rh chiral catalytic system in asymmetric hydroformylation\[J\]. Journal of Qingdao University of Science and Technology（Natural Science Edition),2017,38(2)：18-26.
New Progress of P-Rh Chiral Catalytic System in Asymmetric Hydroformylation
LYU Zhiguo, LI Xingxing, GUO Zhenmei
(College of Chemical Engineering，Qingdao University of Science and Technology，Qingdao 266042，China)
Abstract: Chirality is closely related to the phenomena of life. Asymmetric catalytic synthesis by chiral catalysts is the most effective method to obtain chiral compounds. Because of the high reactivity and selectivity merits, the optical active aldehyde obtained from the asymmetric hydroformylation of olefins catalyzed by Rhodium complexes with phosphine ligands play an important role in the synthesis of drugs, pesticides, perfumes and natural products. The article describes the possible reaction mechanism of the asymmetric hydroformylation reaction, which mainly introduces the applications of several representative chiral phosphine ligands in this kind of reactions, the progress of various chiral phosphine ligands, and the problems in the chiral synthesis. The application prospect of chiral ionic liquid catalyst in industrial has also been prospected.
Key words:chiral ligands; asymmeteic hydroformylation(AHF); rhodium metal; olefin
收稿日期：2016-07-23
基金项目：国家自然科学基金项目(NSFC21376128，20776071)；山东省自然科学研究基金项目(ZR2012BL02)；山东省高校科研计划研究项目(J10LB07).
作者简介：吕志果(1967—),男，教授,博士生导师.
文章编号：1672-6987（2017）02-0018-09；DOI：10.16351/j.1672-6987.2017.02.002
