2-甲基-4-三氟甲基-5-噻唑甲酰胺类化合物的合成及其应用

王明慧, 李秀国, 许良忠*

(青岛科技大学 化学与分子工程学院，山东 青岛 266042)

摘要： 利用2甲基4三氟甲基噻唑甲酰氯与苯胺类化合物进行酰胺化反应，合成了8种新的未见报道的2甲基4三氟甲基5噻唑甲酰胺类化合物，通过1H NMR和元素分析等手段进行表征确定。测定了化合物的杀菌活性，所有目标化合物对黄瓜灰霉和花生褐斑病菌抑菌效果良好，部分化合物对黄瓜灰霉的抑菌率达81%，远高于对照药剂噻呋酰胺。

关键词： 噻唑甲酰胺； 2甲基4三氟甲基噻唑甲酰氯； 酰胺化； 杀菌活性

中图分类号： TQ 460.3              文献标志码：  A

Synthesis and Application of 2Methyl4trifluoromethyl5thiazole Carboxamides

 WANG Minghui， LI Xiuguo，  XU Liangzhong

(College of Chemistry and Molecular Engineering， Qingdao University of Science and Technology, Qingdao 266042，China)

Abstract：  Eight 2methyl4trifluoromethyl5thiazole carboxamides were synthesized by reaction of 2methyl4trifluoromethyl5thiazole chloride with aniline derivatives.Their structures were characterized by 1H NMR and elemental analysis. Fungicidal activity of compounds were tested. All the target compounds of the Botrytis cinerea and the Cercospora rachidicola showed good inhibitory effect. Some compound of the Botrytis cinerea inhibition rate reach 81%, much higher than the control drug Thifluzamide.

Key words:  thiazole carboxamide; 2methyl4trifluoromethyl5thiazole chloride; amidation; fungicidal activity

 收稿日期： 20140117

作者简介： 王明慧（1966—），男，副教授.           *通信联系人.