PDF全文下载：2011060551
张金秋1， 包木太1*， 刘占军2
(1.中国海洋大学 海洋化学理论与工程技术教育部重点实验室， 山东 青岛 266100; 2.河北联合大学 药学院， 河北 唐山 063000)
摘要： 应用壳聚糖与甲基丙烯酸甲酯（MMA）通过自由基聚合反应，以硝酸铈铵为引发剂合成一种功能新颖的药用纳米粒子，作为药物的载体材料，与药物结合后可以调节药物释放速度，减少给药次数，从而增加药物治疗的安全性、高效性和可靠性。研究结果表明，硝酸铈铵可以较好地引发接枝反应，当反应温度为50 ℃，反应时间为4 h，壳聚糖0.6 g、甲基丙烯酸甲酯6 mL、硝酸铈铵0.9 g、1%醋酸300 mL时，合成的纳米粒粒径最小,平均粒径在179 nm左右。体外溶出实验表明，当n(阿司匹林)∶n(壳聚糖)=1∶1时，制备出的纳米粒载药量、包封率较高，可达72.1%，载药纳米粒在16 h内对药物有良好的缓释作用，具有较好的应用前景。
关键词： 壳聚糖； 接枝共聚； 纳米粒； 硝酸铈铵； 药物缓释
中图分类号： O 636.1文献标志码： A
Preparation and Properties of Medical Chitosan Nanoparticles
ZHANG Jin-qiu1, BAO Mu-tai1, LIU Zhan-jun2
(1.Key Laboratory of Marine Chemistry Theory and Technology, Ministry of Education,Qcean University of China, Qingdao 266100, China;
2.College of Pharmacy,HebeiUnited Univesity,Tangshan063000,China)
Abstract: Chitosan and methyl methacrylate(MMA) were prepared into novel-functional medical nanoparticles through radical polymerization. Nanoparticles loaded with medicine can regulate degree of releasing, and reduce deliver time, in order to increase safety, high-effect and dependment of medication as a carrier material of medicine. It is showed that ammonium ceric nitrate is a good initiator in graft reaction. The grain diameter of compounded nanoparticle is minimized into 179 nm on average when temperature is 50 ℃, reacting time 4 h, chitosan 0.6 g, MMA 6 mL, ammonium ceric nitrate 0.9 g, and 1% acetic acid 300 mL. The vitrorelease test shows that the drug-loading rate and envelop rate is up to 72.1%, and nanoparticles works well in sustained-releasing medicine when the proportion of aspirin and chitosan reaches 1∶1.
Key words: chitosan; graft copolymerization; nanoparticles; ammonium ceric nitrate; sustained-release
收稿日期：2011-09-10
基金项目： 青岛市应用基础研究计划项目（09-1-3-17-jch）；国家海洋局海洋溢油鉴别与损害评估技术重点实验室开放基金项目（201014，201104）.
作者简介： 张金秋（1988—）, 女, 硕士研究生.*通信联系人.
