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文章编号： 1672-6987（2022）04-0047-06； DOI： 10.16351/j.1672-6987.2022.04.007
李国梁， 李浩， 王玮*， 陈克正*(青岛科技大学 材料科学与工程学院，山东 青岛 266042)
摘要： 光热疗法是一种微创的肿瘤治疗方法，在外部光源的照射下，利用事先注射入肿瘤的光热转换材料，在肿瘤内部生热来杀死癌细胞。研究采用仿酶绿色合成工艺合成了水溶性和高生物相容性聚苯胺，在近红外区有较强的吸收，光热转换效率为396%。体内抗肿瘤实验中，在808 nm激光照射下能有效消融肿瘤，小鼠存活率为83%，且35 d内未发现肿瘤复发。实验结果证明：所合成的聚苯胺可以作为新型光热治疗剂用于肿瘤的光热治疗。
关键词： 仿酶绿色合成； 水溶性； 聚苯胺； 肿瘤； 光热疗法
中图分类号： R 730.5文献标志码： A
引用格式： 李国梁，李浩，王玮，等. 水溶性聚苯胺的制备及其在肿瘤光热疗法中的应用［J］. 青岛科技大学学报(自然科学版), 2022, 43(4): 47-52.
LI Guoliang, LI Hao, WANG Wei,et al.Preparation and application of water-soluble polyaniline in photothermal therapy of tumor［J］. Journal of Qingdao University of Science and Technology（Natural Science Edition), 2022， 43（4）： 47-52.
Preparation and Application of Water-soluble Polyaniline
in Photothermal Therapy of Tumor
LI Guoliang, LI Hao, WANG Wei, CHEN Kezheng
(College of Materials Science and Engineering, Qingdao University of Science and Technology, Qingdao 266042, China)
Abstract: Photothermal therapy (PTT) is tumor treatment strategy with minimal invasive injury. In PTT, tumor cells are killed by overheating effects caused by photothermal agents that are injected into tumors prior to external light irradiation. In this study, polyaniline (PANI) has intrinsically water-solubility and excellent biocompatibility which is synthesized via a green enzyme mimetic route. The prepared polymer can strongly absorb energy of near infrared (NIR) light, and convert the light energy into heat with a converting efficiency of 396%. In vivo anti-tumor experiments, the prepared polymer can ablate tumors under 808 nm laser irradiation with a survival rate of 83%. No tumor recidivation is found within 35 d. The results of anti-tumor experiments demonstrate that the prepared polymer can be used as a novel therapeutic agent in PTT.
Key words: enzyme-mimetic green synthesis; water-soluble; polyaniline; tumor; photothermal therapy
收稿日期： 2021-08-19
基金项目： 山东省自然科学基金项目(ZR2018MEM016).
作者简介： 李国梁(1983—),男,博士研究生.*通信联系人.
