聚甘露糖醛酸胶束的制备及其载药性能

全文下载： 202201003.pdf

文章编号： 1672-6987（2022）01-0021-07； DOI： 10.16351/j.1672-6987.2022.01.003

孙家曦1, 王腾斌2， 陈祥艳1， 张永勤2*（1.中国海洋大学 海洋药物教育部重点实验室；山东省糖科学与糖工程重点实验室，山东 青岛 266003；

2. 青岛科技大学 化工学院，山东 青岛 266042）

摘要： 以脱氧胆酸为原料通过碳二亚胺法成功制备了聚甘露糖醛酸两亲性聚合物胶束（PM-cc-DA），并通过评估PM-cc-DA胶束的理化性质和载药性能来确定PM-cc-DA最佳制备方法。结果表明所制备PM-cc-DA胶束为均匀球状胶束，粒径为186 nm，PDI为0186，具有良好粒径分布，其临界胶束浓度为673 mg·L-1，这表明胶束具有一定的稳定性。所制备载药胶束其载药量及包封率为137%及692%，载药性能较好，并且PBS溶液中36 h内释药量为254%，对药物的保护能力较好，有望成为递送抗肿瘤药物的理想的胶束材料。

关键词： 聚甘露糖醛酸； 胶束； 乙二胺； 脱氧胆酸

中图分类号： R 943文献标志码： A

引用格式： 孙家曦, 王腾斌， 陈祥艳， 等. 聚甘露糖醛酸胶束的制备及其载药性能［J］. 青岛科技大学学报(自然科学版), 2022, 43(1): 21-27.

SUN Jiaxi, WANG Tengbin, CHEN Xiangyan, et al. Preparation of poly mannuronic acid micelle and drug-loading ability［J］. Journal of Qingdao University of Science and Technology（Natural Science Edition), 2022， 43（1）： 21-27.

Preparation of Poly Mannuronic Acid Micelle and Drug-loading Ability

SUN Jiaxi1, WANG Tengbin2, CHEN Xiangyan1, ZHANG Yongqin2

(1. Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China,

Qingdao 266003, China; 2. College of Chemical Engineering，Qingdao University of Science and Technology，Qingdao 266042，China)

Abstract: The polymannuronic acid amphiphilic polymer micelles (PM-cc-DA) were successfully prepared by the carbodiimide method using deoxycholic acid as raw materials, and the physicochemical properties and loading of PM-cc-DA micelles were evaluated. The PM-cc-DA bland micelles were prepared which were uniform spherical shapes with particle size of 186 nm and PDI of 0186. The critical micelle concentration was 673 mg·L-1 which means good stability in dispersed medium. PM-cc-DA/DOX prepared successfully and its drug loading and encapsulation efficiency was 137% and 692%, 254% DOX was released for PM-cc-DA/DOX micelle in PBS medium. Polymannuronic acid has the potential to be an ideal micellar material for the antitumor drug delivery system.

Key words: polymannuronic acid; micelle; ethylenediamine; deoxycholic acid

收稿日期： 2021-04-15

基金项目： 山东省重点研发计划项目(2019GSF107081)；青岛市科技民生计划项目（17-6-3-28-gx）.

作者简介： 孙家曦（1992—），男，硕士研究生.*通信联系人.