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莫志超1,刘青2,时东陆2,赵健*1
(1.青岛科技大学 橡塑材料与工程教育部重点实验室/橡塑材料与工程山东省重点实验室，山东 青岛266042；2.同济大学 生物医学工程与纳米科学研究院，上海200092)
摘要:聚乳酸具有良好的生物相容性以及可降解性能，但其强疏水性能一定程度上限制了其在可降解支架领域的应用。本研究利用氩气（Ar）低温等离子技术在PDLLA血管支架表面接枝亲水性的聚合物聚乙烯吡咯烷酮（PVP）以及聚醋酸乙烯酯（PVAc）。接触角测试表明，经等离子接枝的材料表面接触角由原来的105°~110°可降至22°，由强疏水性变为亲水性。体外细胞粘附性实验表明：等离子处理后的材料表面表现出亲水性质，其细胞的粘附性也得以明显提高，更加有利于细胞在其表面的生长。
关键词:聚乳酸血管支架； 低温等离子接枝； 聚乙烯吡咯烷酮； 聚醋酸乙烯酯； 亲水性； 细胞粘附性
中图分类号：O 063文献标志码：A
引用格式：莫志超,刘青,时东陆，等.低温等离子接枝改性聚乳酸支架的亲水性\[J\].青岛科技大学学报（自然科学版），2017，38（2）：54-58.
MO Zhichao，LIU Qing，SHI Donglu,et al.PDLLA stent modified by low temperature plasma grafting and its hydrophily \[J\].Journal of Qingdao University of Science and Technology（Natural Science Edition),2017,38(2)：54-58.
PDLLA Stent Modified by Low Temperature Plasma Grafting and Its Hydrophily
MO Zhichao1， LIU Qing2， SHI Donglu2， ZHAO Jian1
(1.Key Laboratory of Rubber-Plastics，Ministry of Education/Shandong Provincial Key Laboratory of Rubber-Plastics, Qingdao University of Science and Technology, Qingdao 266042, China；2.The Institute for Advanced Materials and Nano Biomedicine, Tongji University, Shanghai 200092, China)
Abstract: Polylactic acid has good biological compatibility and biodegradable properties, but to some extent, its strong hydrophobicity limits its development in the field of biodegradable stents. In this work, Ar low temperature plasma technology was applied to graft hydrophilic polymer polyvinylpyrrolidone (PVP) and polyvinyl acetate (PVAc) on the surface of PDLLA stent. Contact angle test showed that surface contact angle of the plasma grafted stent can fall from 105°—110° to 22°, implying a change from strong hydrophobicity to hydrophilicity. In vitro cell adhesion experiments showed that, after plasma treatment, the surface of the material is hydrophilic and the cell adhesion were significantly improved, facilitating the cellgrowth.
Key words: PDLLA vascular stent； low-temperature plasma grafting; polyvinylpyrrolidone (PVP)； polyvinyl acetate (PVAc)； hydrophilic； cell adhesion
收稿日期：2015-09-01
基金项目：国家自然科学基金资助项目(50390090).
作者简介：莫志超(1990—)，男，硕士研究生.*通信联系人.
文章编号：1672-6987（2017）02-0054-05；DOI：10.16351/j.1672-6987.2017.02.008
