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徐新杰， 王小玉， 侯万国*
（青岛科技大学 化学与分子工程学院， 山东 青岛 266042）
摘要: 采用离子交换法制备了苯丁酸氮芥(CHL)-层状双金属氢氧化物(LDHs)纳米杂化物，并用XRD、FT-IR和TEM进行了表征，其载药量分别为3.8%和11.5%。分别在pH 4.8和7.2的介质中研究了药物释放动力学，表明所制备的CHL-LDHs纳米杂化物具有明显的缓释效果，且pH 7.2时苯丁酸氮芥从纳米杂化物中的释放速率明显低于pH 4.8时的释放速率，释放动力学过程符合准二级动力学方程。表明CHL-LDHs是有发展潜力的新型药物控释体系。
关键词: 层状双金属氢氧化物； 苯丁酸氮芥； 离子交换法； 纳米杂化物
中图分类号:O 614文献标志码： A
Preparation and Property of Chlorambucil-LDHs Nanohybrids
XU Xin-jie，WANG Xiao-yu， HOU Wan-guo
(CollegeofChemistryand Molecular Engineering,QingdaoUniversityof
Science and Technology,Qingdao266042,China)
Abstract: Chlorambucil-LDHs nanohybrids were prepared by an ion-exchange method, and were characterized by XRD, FT-IR, and TEM. The loaded chlorambucil in the nanohybrids was up to 3.8% and 11.5% in weight. The release kinetics of chlorambucil from the nanohybrids was investigated at pH 4.8 and 7.2 buffer solutions, respectively. The in vitro drug release from the nanohybrids was remarkably lower than that from the corresponding physical mixture. The release rate of chlorambucil from the nanohybrids at pH 7.2 buffer solution is remarkably lower than that at pH 4.8 buffer solution, and the release processes may fit the pseudo-second-order release kinetics, indicating that the nanohybrids can control the release of chlorambucil. The drug-nanohybrids, thus, can be considered as a potential drug-delivery system.
Key words: layered double hydroxides; chlorambucil; ion-exchange; nanohybrids
收稿日期:2011-04-02
基金项目: 国家自然科学基金项目(50772062，20903059)；山东省泰山学者基金项目(ts20070713)；山东省博士基金项目(2008BS04013，BS2009CL025).
作者简介: 徐新杰(1985—)，男，硕士研究生.*通信联系人
