PDF全文下载：2011010046
吕明， 黄山*
(青岛科技大学 化工学院，山东 青岛 266042)
摘要: 采用固体分散技术制备葛根素亲水凝胶缓释片。先采用单因素实验制备葛根素固体分散体，然后通过正交试验考察HPMC的K4M型和K15M型的质量比m (K4M) ∶m (K15M) (A)，HPMC的质量分数 (B)，淀粉与乳糖质量比m(淀粉)∶m(乳糖)(C)，淀粉与乳糖合计的质量分数 (D)4个因素对葛根素亲水凝胶缓释片的影响。得到葛根素固体分散体的最佳制备工艺：以PEG4000为载体，药物与载体的质量比为1∶6；葛根素亲水凝胶缓释片的最佳制备工艺为：HPMC的K4M型和K15M型质量比m(K4M)∶m(K15M)=1∶2，HPMC的质量分数为片重的30%，淀粉与乳糖的质量比m(淀粉)∶m(乳糖)=1∶3，淀粉与乳糖合计的质量分数为片重的40%。该缓释片处方合理，工艺可行，达到缓释的预期目的。
关键词: 葛根素； 固体分散技术； 亲水凝胶缓释片； 正交设计
中图分类号: R 944.9 文献标志码： A
Preparation of Puerarin Hydrophilic Sustained-release Tablets Using Solid Dispersion Technology
LV Ming, HUANG Shan
(College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao 266042, China)
Abstract: Puerarin hydrophilic sustained-release tablets were prepared using a solid dispersion method. A single factor experiment was prepared for puerarin, and orthogonal design was carried out to investigate the effect of the ratio of HPMC m (K4M) ∶ m (K15M) (A), the mass fraction of HPMC (B), mass ratio of starch and lactose m (starch) ∶m (lactose) (C), and total starch and lactose content (D) on puerarin hydrophilic sustained-release tablets. The optimal preparation method of puerarin solid dispersion was regarded PEG4000 as the carrier, and the quality of drug and carrier ratio as 1∶6. The best preparation of puerarin hydrophilic sustained-release tablets was the ratio of HPMC m (K4M)∶m (K15M) as 1∶2, mass fraction of HPMC as 30%, mass ratio of starch and lactose m (starch) ∶m (lactose) as 1∶3, and total starch and lactose content as 40%. The prescription and technology of the sustained release tablets was reasonable, and achieved the desired objective of sustained-release.
Key words: puerarin; solid dispersion; hydrophilic sustained-release tablets; orthogonal design
收稿日期:2010-09-20
作者简介: 吕明(1983—)，男，硕士研究生. *通信联系人.
