全文下载： 
202603011.pdf
文章编号：1672-6987（2026）03-0089-09；DOI：10. 16351/j. 1672-6987. 2026. 03. 011
谭远航 a ，周现锋 b* （青岛科技大学 a. 高分子科学与工程学院；b. 材料科学与工程学院，山东 青岛 266042）
摘 要：光热治疗是一种新型肿瘤治疗方式，光热治疗剂在体外光源的照射下，可以使肿瘤部 位快速升温，触发热消融机制，从而杀死肿瘤细胞。研究采用了具有活性氧刺激响应性的硫 缩酮键与光热治疗剂连接，构筑了具有活性氧刺激响应的靶向超分子光热诊疗体系。响应前 后的光热效果对比证实了刺激响应后的光热稳定性大幅提升，光热转换效率提高，可以实现 靶向肿瘤的光热诊疗效果。细胞实验中纳米粒子成功进入细胞，并表现出优异的生物安全 性，通过对细胞的模拟实验证明了刺激响应性光热治疗的有效性。
关键词：光热治疗；刺激响应；靶向治疗；活性氧
中图分类号：R 730. 5 文献标志码：A
引用格式：谭远航，周现锋 . 针对肿瘤活性氧微环境构筑的刺激响应型靶向超分子光热诊疗 体系［J］. 青岛科技大学学报（自然科学版），2026，47（3）：89-97.
TAN Yuanhang， ZHOU Xianfeng. A stimulus-responsive targeted supramolecular photother⁃ mal diagnosis and treatment system based on high reactive oxygen species in tumor microenvi⁃ ronment［J］. Journal of Qingdao University of Science and Technology（Natural Science Edi⁃ tion），2026，47（3）：89-97.
A Stimulus-Responsive Targeted Supramolecular Photothermal Diagnosis and Treatment System Based on High Reactive Oxygen Species in Tumor Microenvironment
TAN Yuanhanga ，ZHOU Xianfengb （a. College of Polymer Science and Engineering；b. College of Materials Science and Engineering， Qingdao University of Science and Technology，Qingdao 266042，China）
Abstract：Photothermal therapy represents a novel tumor treatment strategy. Upon irradiation with external light sources， photothermal agents rapidly raise the temperature at tumor sites to trigger thermal ablation， thereby achieving tumor cell killing. Herein， a ROS-responsive thio⁃ ketal bond was utilized to link with a photothermal therapeutic agent， fabricating a targeted supramolecular photothermal theranostic platform with ROS stimulation responsiveness. Com⁃ parisons of photothermal performance pre- and post-response revealed remarkable enhance⁃ ment in photothermal stability and elevated photothermal conversion efficiency after stimula⁃ tion， which could realize targeted photothermal theranostics for tumors. In vitro cellular assays indicated that the nanoparticles successfully entered cells and possessed favorable biosafety， and cell simulation experiments further verified the effectiveness of the stimulus-responsive photothermal therapeutic approach.
Key words：photothermal therapy； stimulus-responsive； targeted therapy； high reactive oxygen
收稿日期：2025-05-30
基金项目：国家自然科学基金项目（51773107）.
作者简介：谭远航（1998—），男，硕士研究生 . ∗ 通信联系人
